| CASE REPORT |
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| Year : 2022 | Volume
: 2
| Issue : 2 | Page : 138-142 |
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BRAF/Mitogen-activated extracellular signal-related kinase inhibitors induced sarcoid-like reaction in patients with refractory localized conjunctival melanoma: A rare case report
Susan Kennedy1, Karina Kulakova1, John Crown2
1 National Ophthalmic Pathology Laboratory, Royal Victoria Eye and Ear Hospital; Research Foundation, Royal Victoria Eye and Ear Hospital, Dublin, Ireland; School of Biotechnology, Dublin City University, Dublin, Ireland
2 Department of Oncology, St. Vincent's University Hospital, Dublin, Ireland
Correspondence Address:
Dr. Susan Kennedy
National Ophthalmic Pathology Laboratory, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin 2
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/jpo.jpo_14_22
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We present a rare case of a patient with refractory localized conjunctival melanoma (CM) who was treated with BRAF/mitogen-activated extracellular signal-related kinase inhibitors in the absence of systemic metastasis. The patient had complete remission and developed a local sarcoid-like reaction. To our knowledge, this is the first report of this complication in a patient with locally advanced CM which emphasizes the local complication of BRAF inhibition.
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